As mentioned before, Lazarus Lee hasn't really dealt with villains that she couldn't manage. She's really beloved in Lake Erie City because she focuses on things other than the big stuff. Such as saving cats from trees, getting frisbees off roofs, and dealing with smaller-scale supercrime. It's not exactly petty supercrime, and there often is a challenge, but it's usually the kind of supercrime that slips through the cracks.

Like Jumpstart, who had the ability to telekinetically manipulate coffee. A coffeekinetic, if you will. Jumpstart was actually a co-worker at Brewed Awakenings. They had a bit of a spending problem so they were always looking for cash. But they weren't looking into getting into robbing banks or jewelry stores. They mostly robbed other coffee shops and everyone in them. It was never determined why they decided to stick to coffee shops, but it's been said that they just thought it would be an easier time overall. Their choice of weapon was coffee hot enough to scald. This is something that's very much a problem for most other people but is not something that Lazarus Lee has to worry about much. It still hurt though and Jumpstart is surprisingly agile. But in time, they were eventually defeated.

There's also The Phisherman. He could jump into the Internet. He mainly used this power to steal people's personal information. He actually amassed a considerable fortune from doing this. He even discovered Lazarus Lee's secret identity, Danielle Chang. So Lazarus Lee was especially motivated to stop him. He also had the ability to download information from the Internet into his brain. That sounds better than it actually is. He just had the information. He had little idea how to interpret most of it. The most success he had was an ability to kind of fight because of a bunch of training videos he downloaded. Since LL didn't know how to fight, she had a lot harder time with him than you'd think. 

Then there's Zoo Queen. She was very invested in finding a way to turn her power to communicate with animals into something that would grant her personal gain. She tried to start an organized crime syndicate with animals. Nobody really knows where she kept getting bears, tigers, and lions and stuff. None of them were actually from the zoo. Also it's very hard to discern when a lion is trying to shake you down for money. She finally realized that she should attach speakers to the animals so she could give her demands. Lazarus Lee is not a big fan of fighting animals. Not just because it often can be painful and sometimes deadly,  but because she just didn't think it was right. This is one villain that Lazarus Lee hasn't really put the lid on yet. 

This time though, she was specifically tasked with taking down Bite Mark. It was decided that she stood one of the best chances of actually defeating her due to the ability to regenerate/resurrect. But as it was stated earlier, this is a challenge unlike she's ever seen.