Outside of wrestling and the supervillain rooftop battle, Izzy hasn't had many scrapes. Although there was that time in 7th grade when she got in a fight with Wanda Pierce. Izzy and Wanda got into an argument that escalated out of control and Wanda ripped off Izzy's synthetic skin in anger. Izzy willingly tolerates a lot of things, perhaps too many things, but she couldn't tolerate that. So she punched Wanda. Wanda retaliated. 

At the time Izzy's right arm was way less powerful. She also was completely unskilled in any kind of physical matchup. But in the end she prevailed Along with a black eye, she also got BIC for a week. During lunch period when other kids asked about her black eye she kept wanting to say something cool like "You should see the other girl." But this was deflated by the fact that Wanda was also in BIC and Izzy's complete inability to gloat. 

Izzy has not gotten any better at gloating. But at least she can hold her own.